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Hydroxocobalamin, the form most commonly used in the UK, may cause: Injection site reactions (pain, redness, or swelling) Temporary reddish discolouration of urine Rarely, hypersensitivity reactions Very rarely, hypokalaemia in severely deficient patients when treatment is initiated (potassium levels should be monitored in severe deficiency) B12 injections are considered very safe, with no upper tolerable limit established, as excess B12 is excreted in urine

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A well-known study from UCLA found that B12 supplementation alters the gene expression of C- acnes (formerly P-acnes ), the bacterium linked to acne

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In rare cases, a person may develop more severe complications

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