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Metabolomic profiling further reinforced our findings, showing substantial overlap between species in pathways such as glutathione synthesis, tRNA charging, NAD signaling, and urea cycle signaling, as well as affected organelles (e.g., mitochondria, peroxisomes, and ER)
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(4) aligning the highly conserved modules to the gene expression profiles perturbed by small molecular compounds in CMAP database 41,42 , and identifying the gene expression profiles enriched in genes from the conserved modules
