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Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]
[PubMed: 11316785] 81
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Long-term Maintenance: Because the underlying factors persist, ongoing preventive care is essential
A patient who starts with CJC-1295/ipamorelin for GH optimization may later add MOTS-c for metabolic support, or transition to a longevity-focused stack as their priorities shift from performance to healthspan
