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In some cases, oral supplements can lose up to 80% of their nutritional value as they are broken down by stomach acid and enzymes

240,278 The specific mechanism of action has been thoroughly explained in our previous article

[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

Note that vitamin B12 is water soluble

Healthcare providers will determine when it is safe to have another dose