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Erin, Crowley C

Nat Rev Neurol 13(3):171191 Sobowale OA, Parry-Jones AR, Smith CJ, Tyrrell PJ, Rothwell NJ, Allan SM (2016) Interleukin-1 in stroke: from bench to bedside

24 ChengY.GuJ

3.1 Key signaling pathways The molecular mechanisms of macrophage polarization depend on a complex signaling network which centers on maintaining the dynamic balance between the pro-inflammatory M1 phenotype and the anti-inflammatory reparative M2 phenotype ( Figure 1 )

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