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Anatomy and physiology, 10 The respiratory system

Low or moderate concentrations of EGCG (with plasma levels of 10 M) may exert mainly an antioxidant action mediated by EGCG-induced production of low amounts of ROS necessary for the stimulation of signal transduction pathways promoting cell protection [57,58]

Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores

doi: 10.1016/j.atherosclerosis.2013.08.029

The chest x-ray is often a first step in COPD evaluation but is not diagnostic of emphysema