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Retatrutide titration: 1mg to 12mg The retatrutide titration protocol tested in Phase 3 trials follows a five-step escalation: Weeks 1-4: 1mg weekly Weeks 5-8: 2mg weekly Weeks 9-12: 4mg weekly Weeks 13-16: 8mg weekly Week 17 onward: 12mg weekly (maximum dose) The dose doubles at each step (with the exception of the 1mg to 2mg increase), which is a faster escalation rate than either semaglutide or tirzepatide

This study recorded a 0.14mmol/l decrease in LDL in the MK-677 group, in contrast with a 0.12mmol/l increase in LDL with placebo [17]

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This is the bigger risk and it is the reason we insist on a written history first