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IRS-1 and IRS-2 are the most ubiquitously expressed IRS family members, and they are the primary mediators of insulin and IGF-dependent regulation of glucose metabolism and mitogenesis in most cell types (reviewed in [8])

ALS can also be genetically categorized as being either sporadic ALS (SALS) that represents 9095% of all diagnoses and in which there is no known direct genetic contribution to the disease, or familial ALS (FALS) that makes up the remaining 510% of all cases where known genetic mutations such as in SOD1, TDP-43, FUS, and C9ORF72 predominate (Zarei et al., 2015)

Molecular mechanisms of obesity-induced development of insulin resistance and promotion of amyloid-beta accumulation: dietary therapy using weak organic acids via improvement of lowered interstitial fluid pH