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doi:10.1161/CIRCULATIONAHA.105.580332 [15] Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG, Ludwig ML

Don't expect dramatic results

VCP/P97 cooperates With YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

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For a sustained effect and response, a sustained administration of the bioactive molecules and a sufficient quantity of healthy cells in the IVD is required for a response to be produced
