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Sox9 has also been shown to play a specific role in inner AF differentiation during disc development ( Sox9 mutant mice showed that deletion of Sox9 resulted in progressive disc degeneration and alterations in ECM organization indicating that Sox9 expression can also directly impact disc cell survival and ECM maintenance (Tsingas et al., 2020)

To maximize the number of cases in the dysplastic BE group, we included all consecutive cases recorded as LGD or HGD in BE from our histopathology database over the preceding five years at the start of our study