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Fundamentals of Pharmacology

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In contrast, at least 1 of the folate receptors, FR-, is expressed in hematopoietic cells and the kidney proximal tubules, among other tissues (Table 2)

For instance, muscle biopsies from ME/CFS patients have revealed cellular membrane damage, likely attributable to elevated levels of ROS (Pietrangelo et al., A critical question in understanding these conditions is how the observed metabolite differences in ME/CFS, Fibromyalgia, and GWS compare with those seen in other diseases associated with chronic fatigue or cognitive decline