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vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin

15 Although there exists considerable sequence similarity, the sensitivity of these two enzymes to their inhibitor malonyl-CoA differs greatly (CPTIA has a tenfold higher Ki for malonyl-CoA), 15 which makes CPTIA the more prevailing enzyme that accomplishes the rate-limiting step in -oxidation

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