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The link between TMAO and MAFLD was first confirmed by a cross sectional observational study conducted by Chen and colleagues, they detected the plasm TMAO levels of healthy people and patients with MAFLD and found that the TMAO level of patients with MAFLD (0.434 M) is 4.17 times higher than that of healthy controls (0.104 M) (Younossi, 2019)

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Participants were given a combination of Coenzyme Q10 (400 mg/day) and Vitamin E (2,100 IU/day) (Lodi et al., 2001)