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The most common side effects are gastrointestinal in nature, including nausea, vomiting, diarrhea, and constipation

The modes of melanosome transfer from melanocyte to keratinocyte are mainly via cytophagosis, shedding vesicles, exocytosis, and endocytosis [43]

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Retatrutide works as a triple receptor agonist, targeting three key hormonal pathways simultaneously: [1] [4] GLP-1 (glucagon-like peptide-1): Is thought to reduce appetite and slow gastric emptying GIP (glucose-dependent insulinotropic polypeptide): Is thought to enhance insulin secretion and may influence fat metabolism, though human evidence remains limited Glucagon receptor: Has been observed in early studies to increase energy expenditure and promote fat breakdown, though the clinical significance in humans is still being established This triple-action mechanism distinguishes retatrutide from currently approved dual or single agonists