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Tumors have evolved a unique microenvironment, and typically display a more acidic condition, hypoxia, overexpressed reactive oxygen species (ROS), and glutathione (GSH) owing to their rapid proliferation and metabolism (Zhou et al., 2018

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10.1016/j.phrs.2019.104593 Pharmacol

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AOD-9604 is a synthetic peptide derived from human growth hormone (hGH), specifically from amino acids 177-191 of the hGH molecule

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Following mitochondrial permeabilization, pro-apoptotic factors, including cytochrome c, are released into cytosol, leading to the formation of a caspase-activating complex (101,105)

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For the nasal route, reconstitute with BAC water containing NaCl rather than plain BAC water benzyl alcohol alone irritates the nasal lining

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