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There was no difference in age between those with or without brain fog, with age not being associated with BBB dysfunction (Extended Data Fig

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3.2.2 BNIP3/NIX mediated mitophagy NIX, a protein with 50% homology to BNIP3 (Matsushima et al., 1998), binds to the mitochondrial outer membrane through its carboxyl transmembrane domain, thereby initiating mitophagy under ischemic or hypoxic conditions

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