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Metabolites such as 3,4-dihydroxyphenylacetic acid and 3-(4-hydroxy-3-methoxyphenyl) propionic acid may exhibit unique physiological effects beyond those of hesperidin

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We demonstrated that glaucoma-associated metabolic dysfunction in DBA/2 J mice could be reversed with the ketogenic diet through upregulation of monocarboxylate transporters, increased mitochondrial biogenesis, higher antioxidant response, and reduction of inflammation (Harun-Or-Rashid et al., 2018