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In the CT26 + BALB/3T3 group, the costimulatory molecules CD80 and CD86 in DCs around tumor tissues or in the spleen were slightly down-regulated compared to the CT26 group, indicating CAFs inhibitory effect on DC activation

The short answer for most people is yes

For example, in a clinical trial conducted by Wallace et al

Oct 2021;88(10):673-685

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