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Symptoms of a vitamin B12 deficiency include: Anemia Fatigue and weakness Dizziness Memory loss or concentration Rapid heartbeat Excessive bruising Soreness of the mouth or tongue Although there is no solid medical research to support these claims, many people believe that Vitamin B12 is helpful in improving concentration and boosting energy, as well as preventing or improving the following conditions: macular degeneration, a weakened immune system, infertility, sleep disorders, allergies, asthma, skin disorders and heart or kidney problems

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(3) Synthesis of target ( R )-1D228 : To a reaction flask were added 3-(6-oxo-1,6-dihydropyridazin-3-yl)-benzonitrile (2.2 mmol, 0.45 g), the intermediate ( S )-4 (2 mmol, 0.654 g), triphenylphosphine (4 mmol, 1.05 g), and tetrahydrofuran (10 mL, with a water content not greater than 3050 ppm), and stirred at 0C under nitrogen protection for 10 min

In addition, higher drug concentration was also noticeable in the brain areas