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Th2 cytokines are predominantly regulated by STAT6, whereas STAT3 is associated with multiple pruritogens, including IL-6, IL-22, IL-31, OSM, TSLP, and VEGF (109111)

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117,148,149,150,151 The main components of the CoREST complex are HDAC1/2, LSD1, CoREST1/2/3, ZNF217, and PHF21A

In contrast, arid-adapted burrowing frogs can retreat underground during dry periods and form a cocoon from shed skin layers, which acts as a waterproof barrier and allows them to survive prolonged droughts (Tracy et al., 2010)

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