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This metabolic perturbation induces sustained ER stress through unfolded protein overload, culminating in mitochondrial decompensation, exacerbating ROS production and establishing a vicious cycle of mitochondrial decline (153,154)

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The TRPA1 channels are activated by different stimuli including chemicals (mustard oil and cinnamaldehyde) and cold body temperature (17C)

In the absence of strainspecific vaccines, strategies to modulate or prime an appropriate immune response irrespective of the infecting strain could provide protection and reduce the adverse clinical impact of COVID-19 viral infection