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Some cell types, among which the energy-ravenous and stress-sensitive brain neurons, cannot synthesize glutathione endogenously and rely on import from neighboring cells of the glia

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Once in liver, aflatoxin B1 is metabolized by microsomal enzymes cytochrome P-450 3A4 to different metabolites through hydroxylation, hydration, demethylation and epoxidation

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mAPX), cytosol (cAPX), and mitochondria (mitAPX, as a membrane-bound form