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Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(ALPHA) Subunit expression that correlate with enhanced tau phosphorylation

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Neurotoxicol Teratol 25:1122, 2003

proposed a model to predict sensitivity to NAC based on three proteomic pathways (Gly, Ser, Thr/Val, Leu, Ile/Ala, Asp, Glu) that differ among partial responders, complete responders, and stable disease groups (240)

9, 10, 11 Considering these possible pathways, it is not clear, however, which one determinates cisplatin resistance in glioma cells