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however, a subsequent double-blinded, placebo-controlled trial failed to replicate these benefits and even noted exacerbation in some instances

In addition, one study included a randomized, double-blind, placebo-controlled trial to test the efficacy of baclofen as an adjuvant to risperidone [41]
4.1 The effect of natural compounds on insulin in PCOS models 4.1.1 Polyols Artini et al