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For example, miR-21 modulates glycolysis in CD4 + T cells through the PTEN/PI3K/AKT pathway, accelerates the cell cycle, promotes CD4 + T cell polarization toward Th2, and induces fibrogenic cytokine IL-13 expression, which participates in arsenite-mediated fibrosis of the liver [110]

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Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer