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123 PolireddyK.DongR.ReedG.YuJ.ChenP.WilliamsonS.et al (2017)

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Adults take 2 capsules daily, swallow them whole, do not chew them

The rationale is straightforward: a 120kg individual has significantly more tissue volume for the peptide to distribute through than a 70kg individual, which affects both the effective concentration at receptor sites and the perceived intensity of side effects
