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The neuropsychiatric manifestations of thyroid dysfunction and their associated mechanisms are summarized in Table 1

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The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

Botts, S., Ennulat, D., Francke-Carrol, S., Graham, M

This helps explain why patients with extensive surgical trauma or prolonged ischemia often develop a systemic inflammatory response that parallels septic shock, even in the absence of infection ( Importantly, these pathways offer targets for intervention: blocking upstream mtDAMPs release or downstream receptors could blunt the harmful inflammation