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Moharrami Kasmaie et al., 2019

Although it shows a protective effect against hypertension and kidney damage induced by RUPP rats when administered in late gestation, it exacerbates the preeclampsia-like phenotype when given in early gestation, predisposing to a smaller placenta and increasing proteinuria

In addition to S586A, S586G and S586T retained more than 10% activity toward tyrosine, whereas the other mutants showed less than 5% or undetectable activity toward tyrosine or DOPA (Fig

Answers to the questions of how glutathione is transported across the ER membrane and whether any ER glutathione reductase activity exists will increase our understanding of how the cell regulates the glutathione buffer in the ER