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Parkinsonism Relat Disord 15(4):307314 Naskar A, Prabhakar V, Singh R, Dutta D, Mohanakumar KP (2015) Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice

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This work was supported by the NSERC RGPIN-2023-05099 (R.W.)

Although the underlying molecular pathways remain unclear, recent studies have implicated picrosides (iridoid glycosides in P kurroa extracts) in activating Nrf2 pathways, leading to the increased expression of detoxifying enzymes (Soni and Grover, 2019)

Wang L.-X
