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Skupio U, Welte J, Serrat R, Eraso-Pichot A, Julio-Kalajzic F, Gisquet D, et al

Proliferating cells in culture are highly dependent on glutamine, as it is both a key nitrogen donor and carbon supply for the TCA cycle

Similar to albumin, AAT has exposed methionine (Met) residues and a free cysteine at the position 232, which can be attacked by oxidants
Excess GSH diminishes the toxicity of the conjugates, leading to the conclusion that the mechanism of their toxicity depends on the instability of these conjugates, releasing the isothiocyanates [102]

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