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When NNMT becomes overactive, particularly in adipose tissue, it depletes cellular NAD+ reserves while promoting fat storage and metabolic inefficiency

Here is a summary of the most commonly used DSIP dosing protocol based on available reports: Starting DSIP dose: 100mcg administered at night, preferably three hours before bedtime

10.1038/s12276-022-00739-7 18 HuJ.LiuW.ZouY.JiaoC.ZhuJ.XuQ.et al (2024)

DSM-5=Diagnostic and Statistical Manual of Mental Disorders, 5th Edition.
