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Description
Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis
The LR3 (Long R3) modification is a clever bit of bioengineering that dramatically extends its half-life and, crucially, prevents it from being bound and rendered inactive by insulin-like growth factor-binding proteins (IGFBPs) in the bloodstream
J Am Coll Cardiol 2019;73:10402
For cardiovascular health, this means the peptide can potentially influence blood pressure through several complementary mechanisms rather than relying on just one
PMC 3541499
