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Collectively, these results indicate that at disease onset at peak of neutrophil influx and mast cell degranulation occurs in the knees and these precede the persistent inflammatory response that then occurs in the digits

and S.L
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Abstract Recombinant antibodies, including whole antibodies, antibody fragments, antibody fusion proteins or conjugates, and more recently also small antibody mimetics, have found increasing applications as therapeutics, e.g
Sawchenko PE, Arias C