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and Poli G
Especially if the injury is from overusing the tendon
This untreated subgroup appear to have a more severe disease course with higher bilirubin and alkaline phosphatase, and shorter time to transplant, than PSC patients with a normal IgG4 level
[PubMed] [Google Scholar] 282.Benedetti A, Comporti M, Esterbauer H

Yes, severe untreated vitamin B12 deficiency can become dangerous over time