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In our mice model, all the eight indexes, including blood glucose, body weight, blood urea nitrogen (BUN), kidney length/tibial length, kidney weight, micro-albumin urine, serum creatine, and urine creatine, exhibited a significantly higher trend in the DN group except the urine creatine (Figures 8AH)

Specifically, resulting increases in AngI levels are likely converted to Ang(19) and then to AngIII, AngIV, and Ang(37)

doi: 10.1016/J.FCT.2023.113938

Weeks 5 through 8: 4mg once weekly

Glucagon-like peptide-2 reduces intestinal permeability but does not modify the onset of type 1 diabetes in the nonobese diabetic mouse