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Psychiatr Clin North Am 2020;43:229-48

Evidence from observational studies suggests that with longer symptom duration and more profound B 12 deficiency, the likelihood that neurological symptoms will not completely resolve increases.28 People often continue to experience mild neurological symptoms such as poor memory, impaired concentration, and fatigue even after adequate B 12 replacement (eg, therapy according to the BNF suggested treatment regimen)91729 and many patients report they need additional treatment

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As particulates and biofilm accumulate in the media bed, the pressure required to maintain flow increases