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Collectively, these insights underscore ferroptosis as a potent immunologic catalyst capable of reversing T-cell exhaustion and enhancing immunotherapeutic efficacy

Homoarginine serves as an alternative substrate of arginine for all three isoforms of NO synthase and, via N -hydroxy-L-homoarginine, an intermediate formed during NO synthase reaction, as a competitive inhibitor of arginase

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on the other hand, the normal rise in sympathetic activation in response to acute stress is blunted

doi: 10.1016/j.molmed.2011.03.001