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Metformin and phenformin extend lifespan additively and share the same genetic dependency as metformin or phenformin alone In light of the observed variations in metformins pro-longevity effect with different media, while phenformin remains unaffected, we further investigated whether these two drugs have distinct genetic dependencies in aging

Knock-in A knock-in allele of tex-2(yas46[F55C12.5::EGFP^3xFLAG]) was generated using the CRISPR/Cas9 genome editing method 121

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Barbier O., Torra I

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