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Patients develop early-onset neurological manifestations and neurodevelopmental disorders that are currently incurable ( The pathophysiological mechanisms underlying most mitochondrial diseases causing neurodevelopmental disorders are poorly understood

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Side effects tend to be mild and dose-dependent -- injection site reactions, temporary water retention, and mild tingling or flushing

The authors evaluated 70 adult NF1 patients (37 men and 33 women, mean age ca

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