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Table 5 Glutamate transporters in retinal neurons and retinal layers, immunocytochemical localizations

Directly supplementing with oral reduced glutathione (L-GSH), however, presents a fundamental pharmacokinetic challenge: GSH has a plasma half-life of approximately 1.6 minutes, undergoes rapid hydrolysis in the gut by intestinal -glutamyl transpeptidase (-GT), and cannot cross cell membranes intact requiring full breakdown into constituent amino acids and intracellular resynthesis

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It stimulates the NRF-2 pathway by inhibiting its repressor KEAP1 and promoting NRF-2 nuclear translocation