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Molecules 25 (3), 467

Functional studies demonstrate that pathogenic E50K mutation in OPTN increases RGC susceptibility to cell death, which can be rescued by the TBK1 inhibitor Amlexanox [235]

Zhao J, Dong X, Hu X, Long Z, Wang L, Liu Q, et al

doi: 10.1093/hmg/ddu542

Therefore, targeting Bach1-HO-1 signaling and mitochondrial iron overload may serve as potential cytoprotective strategies in pathological conditions associated with oxidative stress
