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Altogether, this shows that WAT and BMAT are not necessary for skeletal patterning but may influence the rate of development

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In addition, pediatric patients with hematologic malignancy or bone marrow failure who received allogeneic hematopoietic stem-cell transplantation and subsequent total body irradiation exhibit trabecular bone loss and abnormal bone microarchitecture with increased bone marrow adiposity (350)

Uncoupling protein 3 (UCP3) has also been shown to promote myogenic differentiation, specifically of type b myotubes in C2C12 cells, with PGC-1 levels increasing in response to UCP3 overexpression [76]