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Malassezia restricta promotes alcohol-induced liver injury

We conducted our search in PubMed, utilizing a carefully selected set of keywords: inflammation, diabetes, type 2 diabetes, type 1 diabetes, insulin resistance, ROS and diabetes, OS and diabetes, inflammation and diabetes, and inflammation and obesity. Our search was specifically tailored to include articles published from January 2010 to December 2023, aiming to encompass over a decade of research advancements

Because the oxidationreduction of Fe 2+ to Fe 3+ requires electron transfer, iron is involved in the electron migration between substrates ( 2+ or Fe 3+ ions and hydrogen peroxide (H 2 O 2 ) to produce highly reactive hydroxyl radicals ( 2+ is a cofactor of lipoxygenases (LOXs) that catalyzes PUFA-containing phospholipids into pro-ferroptotic lipid peroxidation ( 2+ is pumped into the extracellular space through membrane ferritin 1 (SLC40A1/FPN1) to strictly maintain cellular iron homeostasis ( Many studies have demonstrated that iron metabolism-related proteins could be used as targets to regulate ferroptosis