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however, the association with plasma myostatin is surprising and should be related to dialysis conditions, since these patients commonly have higher myostatin levels than general population.136 Similar to other organs, the anabolic response to IGF-1 in skeletal muscle cells is decreased in the context of renal insufficiency.137 This resistance is associated with both, decreased local IGF-1 production and resistance to recombinant IGF-1 administration

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Reid, S., Lu, C., Hardy, N., Casikar, I., Reid, G., Cario-Toumaniantz, C., & Condous, G

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