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Nature 594 , 594598 (2021)

OIPN is thought to arise from DNA damage in sensory neurons, dysfunction of voltage-gated ion channels, increased pro-inflammatory response in certain neurons and peripheral nerves, oxidative stress from DNA adducts in neurons, and eventual neuronal apoptosis [69]

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BPC 157, also known as PLD-116, PL-10, PL14736 [9], or Bepectin [10,11,12,13,14,15,16,17], has recently attracted considerable attention as a potential drug candidate that is stable in acidic environments and has no serious adverse effects [18], although it has been known to cause pain and/or necrosis when injected in an aqueous solution or in physiological saline [19]

Manas A, Swain JR, Kantale SA, et al