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Instead of masking symptoms, they aim to optimize cellular function and biological resilience

"Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes." New England Journal of Medicine , 385(6), 503-515

General peptide behavior studies help advance understanding of molecular interactions and stability factors

Roman Chamomile

While Alnylams Phase III APOLLO-B study hit both key primary and secondary endpoints, the FDA stated in the documents that the effects of patisiran compared to placebo on both endpoints were small, of questionable clinical meaningfulness, and may not be detectable by patients. Major discussion points during the adcomm meeting included whether these key endpoints were appropriate to ascertain clinical meaningfulness in the ATTR-CM population, and panelists expressed varying opinions on whether the magnitude of the benefit seen in trial data was clinically meaningful