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Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study

49 , 50 , 51 , 52 In the canonical pathway of ADO production, ectonucleoside triphosphate diphosphohydrolase1 (CD39) converts ATP to ADP, and then to adenosine monophosphate (AMP)

Life Sci 54:PL63PL68 Sikiric P, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Jagic V et al (1996) Beneficial effect of novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity

Upon tissue disruption, danger-associated molecular patterns (DAMPs) Such as extracellular ATP, high-mobility group box 1 (HMGB1), and uric acid crystals are released from damaged cells [26, 27], while PAMPs from the wound microbiome including lipopolysaccharide (LPS) from Gram-negative bacteria, lipoteichoic acid from Gram-positive bacteria, and bacterial DNA-are detected by pattern recognition receptors (PRRs) such as NLRP3, AIM2, or NLRC4 [28]