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Zonal organization: Articular cartilage has superficial zone (tangential collagen orientation, highest cell density), middle zone (random collagen orientation, largest proteoglycans), deep zone (perpendicular collagen orientation, calcified interface with bone), and tidemark (boundary between calcified and uncalcified cartilage)

167 Muscle strength is another critical component

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Endogenous prion protein conversion is required for prion-induced neuritic alterations and neuronal death