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Description
Steponaitis, G
Wolfram syndrome-1 (WS1) is primarily caused by mutations in the WFS1 gene encoding the ER-resident wolframin protein, presenting with diabetes mellitus, optic atrophy, neurological deficits, and hearing impairment [173]
Nuclear receptors constitute a superfamily of ligand-activated transcription factors, which regulate critical physiological processes including growth, development, hormonal signals, reproduction, and energy metabolism (Sonoda et al., 2008)
5 ShaughnessyCABrevesJP
Lindsay S
