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This results in focal hyperemia with increased tissue metabolism that persists for minutes and is succeeded by a wave of neuronal depolarization and significant oligemia (25)

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Intravitreal antisense oligonucleotide sepofarsen in leber congenital amaurosis type 10: a phase 1b/2 trial

They carry meaningful safety, regulatory, or long-term unknown risk profiles, and we prefer to work with peptides that have a more defined clinical track record and a physician-supervised pathway

KPV adds an anti-inflammatory signaling dimension to the tissue biology profile of the other three components
